Is it possible to rewrite old traumatic fear memories and thus significantly reduce the suffering of many patients? The discovery of memory reconsolidation suggests that this could be much easier than many researchers have long assumed.  This is because new research has shown that our memory hovers in a changeable, protein synthesis-dependent state after each recall. During this time window, it is possible to “update” the memory through interventions (e.g. preventing protein synthesis with anisomycin). (Nader & Hardt, 2009; Nader, Schafe, & Le Doux, 2000). Our memory is therefore much more modifiable than we realize. This opens up many new possibilities for the psychotherapy of anxiety disorders (panic disorder, post-traumatic stress disorder, social anxiety, phobias, agoraphobia, etc.).

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Studies (just a small selection):  Elsey, J. W., & Kindt, M. (2017). Tackling maladaptive memories through reconsolidation: From neural to clinical science. Neurobiology of Learning and Memory, 142, 108-117.

Mallet, C., Chick, C. F., Maatoug, R., Fossati, P., Brunet, A., & Millet, B. (2022). Memory reconsolidation impairment using the β-adrenergic receptor blocker propranolol reduces nightmare severity in patients with posttraumatic stress disorder: a preliminary study. Journal of Clinical Sleep Medicine, 18(7), 1847-1855.

Pigeon, S., Lonergan, M., Rotondo, O., Pitman, R. K., & Brunet, A. (2022). Impairing memory reconsolidation with propranolol in healthy and clinical samples: a meta-analysis. Journal of Psychiatry and Neuroscience, 47(2), E109-E122.

Soeter, M., & Kindt, M. (2011). Disrupting reconsolidation: pharmacological and behavioral manipulations. Learning & Memory, 18(6), 357-366.